Absence of YhdP, TamB, and YdbH leads to defects in glycerophospholipid transport and cell morphology in Gram-negative bacteriaYHDP, TAMB 및 YDBH의 부재는 그람 음성 박테리아에서 글리세로 포스 포스 폴리티드 수송 및 세포 형태의 결함으로 이어진다Research Article Published on 2022-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulate adjust anterograde antibiotic Antibiotic resistance asymmetric Bacterial balance biosynthetic biosynthetic pathways Cell cell envelope cell lysis changes in characterized component contribute Critical Defense effective foundation gram Gram-negative bacteria homeostasis homologues inner leaflet leads lipopolysaccharide LPS maintain maintaining membrane membrane vesicles morphology mutant offer outer membrane overexpression pathway phenotype Phenotypes Protein provide reducing rescued restored sensitivity shedding the cell Therapies Threats translocated Transport understanding vesicles viability [DOI] 10.1371/journal.pgen.1010096 PMC 바로가기 [Article Type] Research Article
In silico prediction of structure and function for a large family of transmembrane proteins that includes human Tmem41b인간 Tmem41b를 포함하는 막횡단 단백질의 대규모 패밀리에 대한 구조 및 기능의 실리코 예측Research Article Published on 2021-03-252022-09-11 Journal: F1000Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] ab initio modelling Analysis autophagy bioinformatics Bioinformatics analysis contact predictions DedA domain early stage early stages embryonic embryonic development evolutionary covariance family feature Features highlight homologue homologues Host include information involved less Local mechanism Pfam domain predicted Protein Data Bank recent rotational symmetry SARS-CoV-2 sequence Sequence analysis shown structural biology tandem repeat Tmem41b transmembrane protein Transport Viral VTT domain [DOI] 10.12688/f1000research.27676.2 PMC 바로가기 [Article Type] Research Article
Elucidating the Antiviral Mechanism of Different MARCH FactorsResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, [키워드] antiretroviral Antiviral Cell comprehensive analysis E3 ubiquitin ligases envelope glycoproteins Factor glycoprotein HIV-1 homologues host restriction factors Human immunodeficiency virus Immunity Infection information intrinsic mechanism Murine leukemia virus plasma membrane Protein Proteins recent reducing restrict retrovirus retroviruses shown transmembrane protein virions viruses [DOI] 10.1128/mBio.03264-20 PMC 바로가기 [Article Type] Research Article
Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in VietnamArticle Published on 2018-02-282023-05-31 Journal: Viruses [Category] Fulltext, 조류인플루엔자, [키워드] bats hepatitis viruses homologues pegiviruses rodents Vietnam [DOI] 10.3390/v10030102 PMC 바로가기 [Article Type] Article
Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns완전한 치킨 BG 일배체형의 시퀀스는 특정 발현 패턴을 가진 두 유전자 계통의 동적 확장 및 수축을 보여줍니다Research Article Published on 2014-06-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin allelic Antigen presentation appear association Autoimmune disease Autoimmune diseases B12 brush border Cell cells change chicken chromosome chromosome 2 CNV complex contraction copy number Deletion domain dynamic Evolution expansion expressed expression family fixed Genes genetic association genetic associations Haplotype haplotypes homolog homologue homologues Human humans identify immune immune gene immune genes Immunity implicated Interaction intestinal involved major histocompatibility complex mammal mammals MHC multigene families multigene family myosin Particular pathogen Pathogens pattern polymorphism promoter promoters Recombination Region scrutiny sequence show single gene species tandem repeats the major histocompatibility tissue tissue expression tissues undergo untranslated regions Variation Viral diseases whole genome [DOI] 10.1371/journal.pgen.1004417 PMC 바로가기 [Article Type] Research Article
Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen정량적 유전 발자국과 특성 강화 분석을 결합하여 세균성 병원체의 적합성 결정 요인 식별Research Article Published on 2013-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major abundance Affect Algorithm Antibiotic resistance approach approach approaches array assortment Author Bacterial bacterial gene bacterial genes benefit bioinformatics candidate gene changes in Combination conjunction conserved dataset deep sequencing deleted determinant determinants Determining diagnostic dissect Diversity DNA binding E. coli effective effort enrichment Escherichia Escherichia coli Factor fitness Follow-up analysis Footprinting found Gene Genes Genetic Genome genomes highest highlight homologue homologues Host hypothetical identify increasingly independent Infection infections insertion investigator investigators isolates Meningitis molecular mouse model Mutagenesis mutant novel observation observations pathogen Pathogenesis pathogenic pathogenic strain pathogenic strains Pathogens phenotypic phenotypic variation phylogenetic distribution promote Quantitative reported required Research resource saturated Sepsis Sequencing shown strain Strains suggested therapeutic therapeutic targets Therapies Tn-seq to define trait transcriptional repressor transposon urinary tract infections variant Variation virulence virulence gene widespread zebrafish [DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article
The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus PathogenesisReview Published on 2012-11-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein accessory proteins acute respiratory syndrome affected caused cellular China coronavirus country Effect eight ENCODE expression functional Genome homologous homologues human-to-human transmission infected individual infected individuals Infection Isolation knowledge membrane mortality rate Novel coronavirus nucleocapsid Open reading frame open reading frames ORFs predicted Protein Proteins reported Research respiratory Respiratory disease resulting role SARS-coronavirus SARS-CoV severe Spread subsequent unique virus [DOI] 10.3390/v4112902 PMC 바로가기 [Article Type] Review